InDragon’s Dogma 2, you will come across several terrifying enemies and monsters during your travels that can kill you in the blink of an eye. Each of these bosses has their own unique attacks that can pose a challenge.
To defeat the toughest of these bosses, you will need all the help you can get, and that involves learning skills from Maisters as well as unlocking advanced vocations. These bosses can drop a lot of valuable items, so it’s definitely worth farming them. Below is a list of some of the most challenging bosses that you will encounter in your journey.

Caliginous Depths
Drops
Medusan Spellbow,Blighting Arrow,Hunk of Rift Crystal,Granite Medusa Bone,Dragon’s Gaze,Ring of Motility,Ferrystone.
Medusa, or the Gorgon, is one of the first bosses that you will encounter in Dragon’s Dogma 2. As it is most likely to be your first encounter with a sturdy creature, you might have a hard time tackling her, especially when you have early-game gear. You can find her lair in Caliginous Depths, which is located in the southeast of Bakbattahl, and before her lair, you will see a lot of people and animals petrified, serving as a warning.

You will want to decapitate her head, but climbing her back and hitting on her neck is not going to be an easy task, and she will surely give a hard time. TheMedusa Headcan be used to petrify enemies, but it can cause decay over time even if not in use, so equip it only when required.
Tiger Eye,Dragon’s Breath,Onyx,Ferrystone,Monster Hide,Gold Ore,Monster Fang,Great Griffin ClawClaw,Miracle Roborant,Jasper,Griffin Pinion.
Next up, we have Griffin, and these creatures can be found almost everywhere on the map. Sometimes, they will also appear when you are travelling in an oxcart. It will use its claws to attack, and it can cover a large range, so dodging the attacks can be quite a challenging task.
Keep in mind that when it reaches low health, it will attempt to flee, so you must be quick to act if you don’t want to encounter it again. Ranged attacks will work best against these bosses. Be aware of its nose dive attack, as it can take you out in mere seconds.

Eastern Forest
Beast-Steak,Jasper,Fine Mincemeat Roborant,Hunter’s Bow,Ferrystone,Labyrinthus,Savagery Extract,Mighty Roborant,Plumed Cap,Minotaur Horn,Monster Hide,Ring of Gallantry,Ring of Acclamation,Wakestone Shard,Ring of Exultation.
Just when you thought that Griffins and Cyclops are the ones you should be vary of, you will be faced with Minotaur and Goreminotaur that will really challenge your skills. They will launch at you with high speed and deal devastating damage so you have to be very prepared before entering a fight with them.

However, they do drop some nice rewards that are worth looking forward to. You can get Ferrystones as a drop if you are lucky enough. It’s weak to fire, so you can use fire spells of Mage against the boss.
Vermund, Crumbling Ruins
Copper Ore,Dappled OreElectrum,Copperstone,Ferrystone,Fuligin Ore,Ring of Resolution,Hunk of Rift Crystal,Godsbeast Scalecoat,Gold Ore,Whitecobble,Magick Medal,Ring of Accrual,Ring of Profusion,Silver Ore,Southron Iron.
One of the most annoying bosses in Dragons Dogma 2 are these stone creatures, as they won’t take any damage with normal attacks. You will only be able to take them down by targeting their weak spots, and that can take you quite a while.

Their weak spots will glow blue, andranged attacks from vocations like Magick Archerwill work best on these bosses. These rocky enemies can also drop valuable items like Ferrystones that can greatly aid your journey.
Aged Beast-Steak,Monster Fang,Wakestone ShardFreakish Mane,Beast-Steak,Tiger Eye.
Next up, we have theChimera and Gorechimera,a fusion of serpent, goat, and lion that are extremely difficult to defeat because of their versatile attacks. When it uses its lion head, it roars before swiping and lunging towards the Arisen, dealing them notable physical damage.
On the other hand, it uses its sturdy head to cast a sleep spell that can cover a great distance. Lastly, it will also use its snake head to throw acid at you and also spit fireballs that, if not dodged, can take away a lot of your health.

Allheal Elixir,Ring of Loquacity,Ferrystone.
The sphinx is one of the monsters that will give you a quest to allow you to farm for plenty of rewards before you can slay it. These quests are not necessary, but they do reward plenty, so consider take on Sphinx’s Game Of Wits and solve her riddles first before battling it.
After you have completed the quest, you can attack the sphinx to start the battle with her. Deal damage to its wings to take it down quickly. You can also make use of theunmaking arrowto take out a large chunk of its health.

Spawns in various regions in Vermund and Melve.
Dragon Scale,Wakestone Shard,Wakestone,FerrystoneWyrmslife Crystal
The counterfeits of the True Dragon Lesser Dragons are extremely vile and will require a lot of preparation to get victorious. Their movement and attacks are very versatile, ranging from lightning, fire, and even huge explosions that can kill instantly.
Some of these bosses will have weak spots like their hearts that can be damaged to defeat them. But that’s not the only threat they pose, as you can also get the Dragonsplague as a result of these battles, which can be pretty annoying to deal with. They are weak against ice, so make sure to use magic spells against the trick.

Waterfall Cave
August Dalmatica,Winter’s Path,Black Crystal,Craos Tine,Prescribed Tranquility,Ferrystone,Hunk of Rift Crystal,Ring of Quickening,Eminent Coat,Wakestone Shard,Stability Extract,Wakestone.
These undead necromancers, accompanied by skeletons and zombies, are one of the toughest and most annoying bosses to defeat. They can cast spells and are very difficult to attack as they constantly float around the arena. The only way to defeat them is by usingranged vocations like Sorcerers, Archers, or Magik Archers.

Therefore, ensure to update your party and mostly add ranged locations before going into a fight with the boss. While you will be fighting the skeletal warriors and undead summoned by Wight, it is important to target the main boss if you want to end the battle as soon as possible.
Illdoers' Resting Place
Dullahan Bone,Hunk of Rift Crystal,Ferrystone, Ring of kullduggery,Giant Hunk of Rift Crystal,Wakestone Shard.
By far, the most difficult boss is the Dullahan or the Headless Horseman. Finding it is a task itself, as it doesn’t appear very often. It can be encountered in the quest called Till Death Do Us Part, and the battle can last for quite a while. Therefore, verify you face it fully prepared. It casts spells that can stun you and also deals damage using spectral magic.
You can call it one of the most toughest enemies so far in Dragon’s Dogma 2 due to its devastating ranged attacks that can take you out in an instant. A great way to tackle the Headless Horseman is to target its eye using ranged spells. It also drops 5000 gold when defeated, along with a lot of precious items.